The fire started just seconds into headlining band Great White's opening song, "Desert Moon," when pyrotechnics set off by the band's tour manager, Daniel Biechele, ignited flammable acoustic foam on both sides of the drummer's alcove at the back of the stage. The pyrotechnics were gerbs, cylindrical devices that produce a controlled spray of sparks. Biechele used three gerbs set to spray sparks 15 feet (4.6 m) for 15 seconds. Two gerbs were at 45-degree angles, with the middle one pointing straight up. The flanking gerbs became the principal cause of the fire. The foam was in two layers, with highly flammable urethane foam over polyethylene foam, the latter being difficult to ignite but releasing much more heat once ignited by the less dense urethane.

The flames were at first thought to be part of the act; only as the fire reached the ceiling and smoke began to billow did people realize it was uncontrolled. Twenty seconds after the pyrotechnics ended, the band stopped playing and lead singer Jack Russell calmly remarked into the microphone, "Wow... this ain't good." In less than a minute, the entire stage was engulfed in flames, with most of the band members and entourage fleeing for the west exit by the stage.

By this time, the nightclub's fire alarm had been activated, and, although there were four possible exits, most people naturally headed for the front door through which they had entered. The ensuing stampede led to a crush in the narrow hallway leading to that exit, quickly blocking the exit completely and resulting in numerous deaths and injuries among the patrons and staff. 462 people were^[1] in attendance, even though the club's official licensed capacity was 404. 100 lost their lives, and about half were injured, either from burns, smoke inhalation, or trampling. Among those who perished in the fire were Great White's lead guitarist, Ty Longley, and the show's emcee, WHJY DJ Mike "The Doctor" Gonsalves. A survivor later stated that she and her fiancee had tried to escape via the west exit, but were stopped by a bouncer stating that that door was "for the band only."

The fire, from its inception, was caught on videotape by cameraman Brian Butler for WPRI-TV of Providence, and the beginning of the tape was released to national news stations. Butler was there for a planned piece on nightclub safety being reported by Jeffrey Derderian, a WPRI news reporter who was also a part-owner of The Station. WPRI-TV would later be cited for conflict of interest in having a reporter do a report concerning his own property.